Axel A Brakhage Selected Research

Gliotoxin

1/2019	Gliotoxin from Aspergillus fumigatus Abrogates Leukotriene B4 Formation through Inhibition of Leukotriene A4 Hydrolase.
1/2018	Reconstitution of Enzymatic Carbon-Sulfur Bond Formation Reveals Detoxification-Like Strategy in Fungal Toxin Biosynthesis.
8/2011	A dedicated glutathione S-transferase mediates carbon-sulfur bond formation in gliotoxin biosynthesis.
10/2006	Deletion of the gliP gene of Aspergillus fumigatus results in loss of gliotoxin production but has no effect on virulence of the fungus in a low-dose mouse infection model.

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Axel A Brakhage Research Topics

Disease

32	Infections 02/2022 - 05/2004
17	Aspergillosis 01/2022 - 01/2002
13	Starvation 07/2021 - 01/2003
9	Mycoses (Diseases, Fungus) 02/2022 - 10/2016
5	Hypersensitivity (Allergy) 06/2021 - 10/2016
5	Hypoxia (Hypoxemia) 01/2019 - 05/2011
4	Invasive Fungal Infections 06/2021 - 01/2012
3	Invasive Pulmonary Aspergillosis 12/2020 - 01/2012
3	Communicable Diseases (Infectious Diseases) 01/2019 - 01/2004
2	Hematologic Neoplasms (Hematological Malignancy) 12/2005 - 01/2002
1	Tuberculosis (Tuberculoses) 12/2021
1	Lung Diseases (Lung Disease) 06/2021
1	Disease Progression 02/2021
1	Dehydration (Water Stress) 01/2021
1	Epilepsy (Aura) 01/2021
1	Respiratory Tract Diseases (Respiratory Tract Disease) 01/2020
1	Drug-Related Side Effects and Adverse Reactions 01/2017
1	Inflammation (Inflammations) 01/2016
1	Candidemia 01/2016
1	Cystic Fibrosis (Mucoviscidosis) 01/2013
1	Hemolysis 11/2011

Drug/Important Bio-Agent (IBA)

16	IronIBA 07/2021 - 10/2008
12	Proteins (Proteins, Gene)FDA Link 02/2022 - 12/2007
6	Reactive Oxygen Species (Oxygen Radicals)IBA 01/2019 - 12/2007
4	EnzymesIBA 12/2021 - 01/2017
4	SiderophoresIBA 07/2021 - 09/2010
4	Transcription Factors (Transcription Factor)IBA 01/2020 - 08/2014
4	GliotoxinIBA 01/2019 - 10/2006
3	AzolesIBA 01/2022 - 01/2016
3	Membrane Proteins (Integral Membrane Proteins)IBA 12/2020 - 05/2012
3	Biological ProductsIBA 01/2020 - 05/2011
3	Oxygen (Dioxygen)IBA 01/2019 - 09/2014
3	Penicillins (Penicillin)FDA Link 10/2018 - 01/2003
3	ProteomeIBA 12/2017 - 12/2007
3	Amino Acids FDA Link 05/2011 - 01/2003
2	AllergensIBA 01/2020 - 01/2017
2	Melanins (Melanin)IBA 01/2020 - 01/2018
2	Pharmaceutical PreparationsIBA 10/2018 - 03/2007
2	Anti-Bacterial Agents (Antibiotics)IBA 10/2018 - 01/2004
2	Basic-Leucine Zipper Transcription FactorsIBA 10/2018 - 05/2017
2	Virulence Factors (Pathogenicity Factors)IBA 01/2018 - 08/2011
2	Peptide Hydrolases (Proteases)FDA Link 01/2017 - 11/2011
2	Lysine (L-Lysine)FDA Link 01/2017 - 05/2004
2	AntigensIBA 11/2016 - 01/2016
2	AntibodiesIBA 01/2016 - 03/2007
2	pyomelaninIBA 01/2012 - 01/2011
2	methylcitrate synthaseIBA 01/2008 - 07/2005
1	MicroRNAs (MicroRNA)IBA 02/2022
1	Nucleic AcidsIBA 02/2022
1	Trinitrotoluene (TNT)IBA 12/2021
1	Interleukin-17 (Interleukin 17)IBA 06/2021
1	CytokinesIBA 06/2021
1	Interleukin-5 (Interleukin 5)IBA 06/2021
1	Interleukin-4 (Interleukin 4)IBA 06/2021
1	C.I. Fluorescent Brightening Agent 28IBA 02/2021
1	AurovertinsIBA 01/2021
1	PyronesIBA 01/2021
1	AnionsIBA 01/2021
1	Polyketide SynthasesIBA 01/2021
1	citreoviridinIBA 01/2021
1	Biomarkers (Surrogate Marker)IBA 12/2020
1	LipidsIBA 01/2020
1	flotillinsIBA 01/2020
1	Complement System Proteins (Complement)IBA 12/2019
1	GlutaredoxinsIBA 01/2019
1	Cysteine (L-Cysteine)FDA Link 01/2019
1	Protein Disulfide-IsomerasesIBA 01/2019
1	LeukotrienesIBA 01/2019
1	Chemotactic FactorsIBA 01/2019
1	ThioredoxinsIBA 01/2019
1	Leukotriene B4IBA 01/2019
1	leukotriene A4 hydrolaseIBA 01/2019
1	SulfurIBA 01/2019
1	Sulfhydryl Compounds (Thiols)IBA 01/2019
1	Arachidonate 5-Lipoxygenase (5 Lipoxygenase)IBA 01/2019
1	Pattern Recognition ReceptorsIBA 01/2018
1	helvolic acidIBA 12/2017
1	MetalsIBA 12/2017
1	Peptides (Polypeptides)IBA 12/2017
1	fumiquinazoline AIBA 12/2017
1	pyripyropene AIBA 12/2017
1	fumagillinIBA 12/2017
1	fusigenIBA 12/2017
1	ChitinasesIBA 01/2017
1	Antifungal AgentsIBA 01/2017
1	Oxidoreductases (Dehydrogenase)IBA 01/2016
1	coenzyme Q10 (CoQ10)IBA 01/2016
1	Immunosuppressive Agents (Immunosuppressants)IBA 10/2015
1	N-formylmethionylphenylalanine (FMP)IBA 04/2015
1	EchinocandinsIBA 01/2015
1	NitrogenIBA 09/2014
1	Messenger RNA (mRNA)IBA 01/2014
1	DNA (Deoxyribonucleic Acid)IBA 01/2013
1	Serine Proteases (Serine Protease)IBA 11/2011
1	aegerolysinIBA 11/2011

Therapy/Procedure

8	Therapeutics 12/2020 - 01/2002
3	Immunotherapy 01/2021 - 10/2016
1	Precision Medicine 01/2019
1	Stem Cell Transplantation 10/2015
1	Transplantation 10/2015